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a first: all respond to gene therapy in a blood cancer studya first: all respond to gene therapy in a blood cancer studya first: all respond to gene therapy in a blood cancer study - pet manufacturing process

by:Cailong     2019-08-25
a first: all respond to gene therapy in a blood cancer studya first: all respond to gene therapy in a blood cancer studya first: all respond to gene therapy in a blood cancer study  -  pet manufacturing process
CHICAGO —
Doctors reported unprecedented success in new cell and gene therapy for mm, a rising blood cancer.
Although the time is early, the research scale is small35 people —
Each patient had a response, and all the other patients had some degree of relief within two months, except for two patients.
In the second study of nearly 20 patients, everyone at a certain dose or more responded.
Experts at the American Society of Clinical Oncology conference in Chicago say this is the first time a multiple mm has occurred, and any cancer treatment has rarely been so successful.
Chemotherapy is helpful to patients from 10 to 30;
Immune system drugs, up to 35 to 40 cents, and some genes
The doctor said the target is 70 to 80 drugs, "but you didn't reach 100"
Len Lichtenfeld, deputy chief medical officer of the American Cancer Society.
"These are impressive results," he said, but time will tell us if they will continue.
This disease affects plasma cells that produce anti-infection antibodies.
There are more than 30,000 cases in the United States every year, and more than 115,000 cases worldwide.
According to the National Cancer Institute, this is the second fastest growing cancer for men and the third fastest growing rate for women, up 2 to 3 percentage points per year.
Nine new drugs have been approved since 2000, but they have not been cured;
Only about half of AmericansS.
The patient survived five years after diagnosis.
In terms of cell therapy, "I can't say we can heal, but at least we have hope for that possibility . "Frank Fan.
He is the chief science officer of Nanjing Legend Biotech, a Chinese company that tests the treatment with doctors at Xi'an Jiaotong University.
How it was treated, called CAR-
T treatment, which includes filtering the patient's blood to remove the immune system soldier known as T cells.
These are changed in the laboratory to contain a gene for cancer and then intravenous to the patient.
The doctor called it "live medicine"a one-
Time treatment, permanently changing the cells that reproduce in the body to the army against cancer.
It shows hope for some leukemia and lymphoma, but this is a new type that is being tried to treat mm in patients with worsening cancer despite many other treatments.
In a Chinese study, 19 out of 35 patients had a long enough treatment time to tell if they were in a state of complete remission and 14 patients had a long enough treatment time.
Cancer in the other five people has been greatly reduced, at least partially relieved.
Some treatments have been around for over a year and there is no sign of any disease.
Most patients have a set of sides
Common effects of this treatment include fever, low blood pressure, and difficulty breathing.
Only two cases are serious and can be treated and temporary, the doctor said.
The second study was conducted in the United States. S.
By Bluebird biology and Celgene, use cell therapy developed by the National Cancer Institute.
It tested four different doses of cells in a total of 21 patients.
From treatment to judging effectiveness, 18 are long enough, and all 15 people who get enough cells respond.
So far, 4 have reached complete remission, and some have been treated for more than a year.
Experts say these results are "very significant" not only because of how many people have responded to this, but also because of how well they have responded.
Kenneth Anderson in Dana
Faber Cancer Institute in Boston
"We need to look for how long these cells last," he said, and control cancer. Dr.
Carl, a researcher at the University of Pennsylvania in June, was awarded the conference's top science award for his early work in Automotive
T treatment, saying "it's very rare to see everyone responding to treatment ".
His lab happened, too.
All 22 children testing new versions of cars
His colleague reported at the meeting that T response to leukemia.
"The first group of patients we treated in 2010 did not recur," said June . ". Dr.
Michael Sabel of the University of Michigan called the treatment "revolutionary ".
"It's really a microcosm of personalized medicine," he said, extending immunotherapy to more types of patients.
Next step, STEPSLegend Biotech plans to continue the study among China's population of up to 100 and plans to conduct a study in the United States. S.
Early next year.
The treatment is expected to cost between $200,000 and $300,000, "and it's a big problem who will pay for it," Fan said . ".
"The manufacturing process is very expensive and you can't scale it up.
It's personalized.
"You can't make a batch like a drug," he said ".
Blue Bird chief executive Nick Leschly said the company's next phase of research would test the ideal dose for another 20 people.
Related Press Chicago-
Doctors reported unprecedented success in new cell and gene therapy for mm, a rising blood cancer.
Although the time is early, the research scale is small35 people —
Each patient had a response, and all the other patients had some degree of relief within two months, except for two patients.
In the second study of nearly 20 patients, everyone at a certain dose or more responded.
Experts at the American Society of Clinical Oncology conference in Chicago say this is the first time a multiple mm has occurred, and any cancer treatment has rarely been so successful.
Chemotherapy is helpful to patients from 10 to 30;
Immune system drugs, up to 35 to 40 cents, and some genes
The doctor said the target is 70 to 80 drugs, "but you didn't reach 100"
Len Lichtenfeld, deputy chief medical officer of the American Cancer Society.
"These are impressive results," he said, but time will tell us if they will continue.
This disease affects plasma cells that produce anti-infection antibodies.
There are more than 30,000 cases in the United States every year, and more than 115,000 cases worldwide.
According to the National Cancer Institute, this is the second fastest growing cancer for men and the third fastest growing rate for women, up 2 to 3 percentage points per year.
Nine new drugs have been approved since 2000, but they have not been cured;
Only about half of AmericansS.
The patient survived five years after diagnosis.
In terms of cell therapy, "I can't say we can heal, but at least we have hope for that possibility . "Frank Fan.
He is the chief science officer of Nanjing Legend Biotech, a Chinese company that tests the treatment with doctors at Xi'an Jiaotong University.
How it was treated, called CAR-
T treatment, which includes filtering the patient's blood to remove the immune system soldier known as T cells.
These are changed in the laboratory to contain a gene for cancer and then intravenous to the patient.
The doctor called it "live medicine"a one-
Time treatment, permanently changing the cells that reproduce in the body to the army against cancer.
It shows hope for some leukemia and lymphoma, but this is a new type that is being tried to treat mm in patients with worsening cancer despite many other treatments.
In a Chinese study, 19 out of 35 patients had a long enough treatment time to tell if they were in a state of complete remission and 14 patients had a long enough treatment time.
Cancer in the other five people has been greatly reduced, at least partially relieved.
Some treatments have been around for over a year and there is no sign of any disease.
Most patients have a set of sides
Common effects of this treatment include fever, low blood pressure, and difficulty breathing.
Only two cases are serious and can be treated and temporary, the doctor said.
The second study was conducted in the United States. S.
By Bluebird biology and Celgene, use cell therapy developed by the National Cancer Institute.
It tested four different doses of cells in a total of 21 patients.
From treatment to judging effectiveness, 18 are long enough, and all 15 people who get enough cells respond.
So far, 4 have reached complete remission, and some have been treated for more than a year.
Experts say these results are "very significant" not only because of how many people have responded to this, but also because of how well they have responded.
Kenneth Anderson in Dana
Faber Cancer Institute in Boston
"We need to look for how long these cells last," he said, and control cancer. Dr.
Carl, a researcher at the University of Pennsylvania in June, was awarded the conference's top science award for his early work in Automotive
T treatment, saying "it's very rare to see everyone responding to treatment ".
His lab happened, too.
All 22 children testing new versions of cars
His colleague reported at the meeting that T response to leukemia.
"The first group of patients we treated in 2010 did not recur," said June . ". Dr.
Michael Sabel of the University of Michigan called the treatment "revolutionary ".
"It's really a microcosm of personalized medicine," he said, extending immunotherapy to more types of patients.
Next step, STEPSLegend Biotech plans to continue the study among China's population of up to 100 and plans to conduct a study in the United States. S.
Early next year.
The treatment is expected to cost between $200,000 and $300,000, "and it's a big problem who will pay for it," Fan said . ".
"The manufacturing process is very expensive and you can't scale it up.
It's personalized.
"You can't make a batch like a drug," he said ".
Blue Bird chief executive Nick Leschly said the company's next phase of research would test the ideal dose for another 20 people.
Related Press Chicago-
Doctors reported unprecedented success in new cell and gene therapy for mm, a rising blood cancer.
Although the time is early, the research scale is small35 people —
Each patient had a response, and all the other patients had some degree of relief within two months, except for two patients.
In the second study of nearly 20 patients, everyone at a certain dose or more responded.
Experts at the American Society of Clinical Oncology conference in Chicago say this is the first time a multiple mm has occurred, and any cancer treatment has rarely been so successful.
Chemotherapy is helpful to patients from 10 to 30;
Immune system drugs, up to 35 to 40 cents, and some genes
The doctor said the target is 70 to 80 drugs, "but you didn't reach 100"
Len Lichtenfeld, deputy chief medical officer of the American Cancer Society.
"These are impressive results," he said, but time will tell us if they will continue.
This disease affects plasma cells that produce anti-infection antibodies.
There are more than 30,000 cases in the United States every year, and more than 115,000 cases worldwide.
According to the National Cancer Institute, this is the second fastest growing cancer for men and the third fastest growing rate for women, up 2 to 3 percentage points per year.
Nine new drugs have been approved since 2000, but they have not been cured;
Only about half of AmericansS.
The patient survived five years after diagnosis.
In terms of cell therapy, "I can't say we can heal, but at least we have hope for that possibility . "Frank Fan.
He is the chief science officer of Nanjing Legend Biotech, a Chinese company that tests the treatment with doctors at Xi'an Jiaotong University.
How it was treated, called CAR-
T treatment, which includes filtering the patient's blood to remove the immune system soldier known as T cells.
These are changed in the laboratory to contain a gene for cancer and then intravenous to the patient.
The doctor called it "live medicine"a one-
Time treatment, permanently changing the cells that reproduce in the body to the army against cancer.
It shows hope for some leukemia and lymphoma, but this is a new type that is being tried to treat mm in patients with worsening cancer despite many other treatments.
In a Chinese study, 19 out of 35 patients had a long enough treatment time to tell if they were in a state of complete remission and 14 patients had a long enough treatment time.
Cancer in the other five people has been greatly reduced, at least partially relieved.
Some treatments have been around for over a year and there is no sign of any disease.
Most patients have a set of sides
Common effects of this treatment include fever, low blood pressure, and difficulty breathing.
Only two cases are serious and can be treated and temporary, the doctor said.
The second study was conducted in the United States. S.
By Bluebird biology and Celgene, use cell therapy developed by the National Cancer Institute.
It tested four different doses of cells in a total of 21 patients.
From treatment to judging effectiveness, 18 are long enough, and all 15 people who get enough cells respond.
So far, 4 have reached complete remission, and some have been treated for more than a year.
Experts say these results are "very significant" not only because of how many people have responded to this, but also because of how well they have responded.
Kenneth Anderson in Dana
Faber Cancer Institute in Boston
"We need to look for how long these cells last," he said, and control cancer. Dr.
Carl, a researcher at the University of Pennsylvania in June, was awarded the conference's top science award for his early work in Automotive
T treatment, saying "it's very rare to see everyone responding to treatment ".
His lab happened, too.
All 22 children testing new versions of cars
His colleague reported at the meeting that T response to leukemia.
"The first group of patients we treated in 2010 did not recur," said June . ". Dr.
Michael Sabel of the University of Michigan called the treatment "revolutionary ".
"It's really a microcosm of personalized medicine," he said, extending immunotherapy to more types of patients.
Next step, STEPSLegend Biotech plans to continue the study among China's population of up to 100 and plans to conduct a study in the United States. S.
Early next year.
The treatment is expected to cost between $200,000 and $300,000, "and it's a big problem who will pay for it," Fan said . ".
"The manufacturing process is very expensive and you can't scale it up.
It's personalized.
"You can't make a batch like a drug," he said ".
Blue Bird chief executive Nick Leschly said the company's next phase of research would test the ideal dose for another 20 people.
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