a review of the pathways of human exposure to poly- and perfluoroalkyl substances (pfass) and present understanding of health effects - food packaging film
Here we look back at the current exposure to humans-
And PFCs (PFASs)
Epidemiology evidence on the effects of cancer, immune function, metabolic outcomes and neurodevelopment.
More than 4000 PFASs have been manufactured by humans and hundreds have been detected in environmental samples.
Direct contact due to use in the product can be quickly eliminated through changes in chemical production, but due to the accumulation of PFAS in the Marine and marine food chains and the contamination of groundwater
Serum concentrations of human legacy PFASs are decreasing globally, but total exposure to newer PFASs and precursor compounds is not well described.
In many regions, human exposure to PFASs left over from seafood and drinking water is stable or increased, suggesting that the observed decline reflects the stage
The use of traditional PFAS in consumer goods.
Many regions around the world are continuing to discover PFAS contaminated sites from water film-forming foam (AFFF)
Especially next to the airport and military base.
Due to the rapid changes in the chemical environment, exposure from food packaging and indoor environments is uncertain, in which traditional PFASs has been subjected to various precursor and custom molecules that are difficult to detect
Multiple studies have found a significant association between PFAS exposure and adverse immune outcomes in children.
Abnormal blood fat is the strongest metabolic result associated with PFAS exposure.
The evidence of cancer is limited to manufacturing sites with extremely high levels of exposure and there is not enough data to characterize the effect of PFAS exposure on neurodevelopment.
Preliminary evidence suggests that exposure to emerging PFASs can have a significant impact on health.
Lessons learned from legacy PFASs suggest that limited data should not be used as a justification for delaying risk mitigation actions to replace PFASs.