tuning drug release in polyester thin films: terminal end-groups determine specific rates of additive-free controlled drug release - thin polyester film
Drug release that regulates the Polyester Matrix independently of material properties will facilitate the design of biodegradable medical implants such as drug delivery devices, brackets, and screws.
However, the most common method is to use additives, which often greatly change the material properties required.
Recently, we have developed a formula that allows gradient film and high
Throughput drug quantification for determining parameters-
We recommend that modulated drug release can be obtained through additives
The free mechanism in polyester is controlled by simply controlling polymer erosion through an acid terminal functional base.
Our results show that (lactic-co-glycolic acid)(PLGA)
Preparations can be adjusted to produce a large range of drug release, with relatively small changes in the terminal acidic functional groups.
For example, the pla 53/47 film can be adjusted to have a drug release of 10-60% within 14 days, or a drug release of 10-90% within 20 days, depending on the pla/pla mixture formula and the concentration of acid terminal functional groups. A linear R-
The square correlation is as high as 0.
The percentage of acid group and drug release was observed to be 9.
Below the threshold of 1 part per thousand acidic bases, drug release has not increased, which has an impact on polymer processing and film integrity.